If a patient sample is tested against an antisera and gentle shaking in tube testing resulted in the above agglutination pattern, how would you describe it and what are some possible etiologies for the result?
This is an example of mixed field agglutination and is indicative of circulating red cells of more than one ABO group.
Etiologies of mixed field agglutination include:
Recent, out of group red cell transfusions
Hematopoietic progenitor cell transplantation
Some ABO subgroups
Chimerism found in cases of fraternal twins
Mosaicism resulting from dispermy
Fung, M. K., Grossman, B. J., Hillyer, C. D., & Westhoff, C. M. (2014). Technical Manual (18th ed.). Bethesda, MD: American Association of Blood Banks.
Skill Sharpener for the Week of 2017 February 13
Skill Sharpener Solutions Here, we hopefully confirm your clinical laboratory knowledge, but if you want to assert a better or more complete answer, or have something to add, speak up, so that we can help all of our fellow KSCLS colleagues and guests.